HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Sulpiride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Methoxy-5-sulfamoylbenzoic acid | HCID 89601 | — |
| Reactant | 1-[(Diphenoxyphosphoryl)oxy]pyrrolidine-2,5-dione | HCID 4386397 | — |
| Reactant | HCID 19022581 | HCID 19022581 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Sulpiride | HCID 5355 | 24% |
Reaction Steps
A solution of 462 mg (0.002 mol) of 2-methoxy-5-aminosulfonylbenzoic acid and 256 mg (0.002 mol) of N-ethyl-2-aminomethylpyrrole in 10 ml of acetonitrile was admixed with 694 mg (0.002 mol) of SDPP and 202 mg (0.002 mol) of triethylamine, and the admixture was stirred overnight at room temperature. The crystalline material deposited was collected by filtration and washed with acetonitrile and then with ethanol to give sulpiride, that is, 5-(aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl) methyl]-2-methoxybenzamide. mp. 182°~185° C. Yield 24%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04341707 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-4034eb5a7ee14249a207b483a594b888 |
| Source note | uspto-grants-1982_07 |