Diethyl Sulfate → HCID 20530992, compound

Participants

Reaction Steps

According to Examples 2 and 3 of German Democratic Republic Pat. No. 9,728, 1-amino-2-ethoxy-naphthalene-6-sulphonic acid, is obtained by a procedure in which, in a first stage, 1-acetamino-2-hydroxy-naphthalene-6-sulphonic acid is prepared from 1-amino-2-hydroxy-naphthalene-6-sulphonic acid by reaction with acetic anhydride in dilute acetic acid, this intermediate product is etherified, in a second stage, with diethyl sulphate or with ethyl chloride in aqueous-alcoholic sodium hydroxide solution to give 1-acetamino-2-ethoxy-naphthalene-6-sulphonic acid, and, finally, this intermediate product is deacetylated, without intermediate isolation, by heating with aqueous sodium hydroxide solution to give 1-amino-2-ethoxy-naphthalene-6-sulphonic acid.

Provenance & Evidence