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M-Cresol → alpha-Hydroxy-beta-(3-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | M-Cresol | HCID 342 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 18-Crown-6 | HCID 28557 | — |
| 反応物 | N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide | HCID 13041334 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | alpha-Hydroxy-beta-(3-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide | HCID 13041341 | — |
反応手順
This compound was prepared as in Example 12 from N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide (6.16 g.), m-cresol (3.3 g.), sodium hydride (50% oil dispersion, 1.5 g.), 18-crown-6 (0.9 g.), and acetonitrile (250 ml.). The product which was recrystallized from ether melted at 158°-159°, and weighed 3.2 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04341718 |
| 出典データセット | uspto-grants-1982_07 |
| ORD ID | ord-c39d6a77b5ff4ca2b8df5e80c383dc12 |
| 出典メモ | uspto-grants-1982_07 |