HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Cresol → alpha-Hydroxy-beta-(2-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Cresol | HCID 335 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 18-Crown-6 | HCID 28557 | — |
| Reactant | N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide | HCID 13041334 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | alpha-Hydroxy-beta-(2-Methylphenoxy)-N-(1-Methylethyl)Benzenepropanamide | HCID 13041342 | — |
Reaction Steps
This compound was prepared from N-(1-methylethyl)-3-phenyl-2-oxiranecarboxamide (8.2 g.) o-cresol (4.3 g.) sodium hydride (50% oil dispersion, 1.9 g.), 18-crown-6 (1.0 g.) and acetonitrile (250 ml.) as described in Example 12. The compound after recrystallization from ether melted at 123°-124°, and weighed 1.25 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04341718 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-0c3340dbf3c545309269f019dfdedb2b |
| Source note | uspto-grants-1982_07 |