HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Acetamidopyrrolidine → 7-(3-Benzyloxycarbonylamino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Acetamidopyrrolidine | HCID 522715 | — |
| Reactant | 3-N-Cbz-aminopyrrolidine | HCID 11206781 | — |
| Reactant | 7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 12790859 | — |
| Product | 7-(3-Benzyloxycarbonylamino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid | HCID 20531186 | — |
Reaction Steps
In place of 3-acetylaminopyrrolidine, 3-benzyloxycarbonylaminopyrrolidine was allowed to react with 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid in the same manner as described in Example 1 to give 7-(3-benzyloxycarbonylamino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid, which was used in the next step:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04341784 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-13b9771948d44a6ea18fa2da5c52ba82 |
| Source note | uspto-grants-1982_07 |