反应详情

3-(N-Acetyl-n-propylamino)pyrrolidine was allowed to react with 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid in the same manner as described above and yield 7-[3-(N-acetyl-n-propylamino)-1-pyrrolidinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Subsequent hydrolysis of this compound with hydrochloric acid gave 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-N-propylamino-1-pyrrolidinyl)-1,8-naphthyridine-3-carboxylic acid hydrochloride, m.p. about 270° C. (decomp.).