HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 1-ethyl-7-(ethylsulfonyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate → HCID 20531187, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 1-ethyl-7-(ethylsulfonyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate | HCID 13290776 | — |
| Reactant | HCID 20531188 | HCID 20531188 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 20531187 | HCID 20531187 | 78.2% |
Reaction Steps
A mixture containing ethyl 1-ethyl-7-ethylsulfonyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate (1.78 g), 3-(N-acetylmethylamino)pyrrolidine (2.13 g), and acetonitrile (70 ml) was heated under reflux for 3 hours. After cooling the mixture, the resulting precipitate was collected and recrystallized from acetonitrile to yield 1.58 g of ethyl 7-[3-(N-acetylmethylamino)-1-pyrrolidinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate, m.p. 212°-213° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04341784 |
| Source dataset | uspto-grants-1982_07 |
| ORD ID | ord-be7e75c546f94653b2a148a13168719e |
| Source note | uspto-grants-1982_07 |