2-(3-Chloro-2,2,3-trifluoro-propionamido)-5-nitrophenol → 2-(3-Chloro-2,2,3-trifluoropropionamido)-5-aminophenol

Participants

Reaction Steps

In an autoclave 267 g (0.895 mole) of compound (b), 18 ml of Raney-nickel suspension, and 1.3 l of ethanol were placed. The nitro group was reduced with hydrogen at a temperature of 65°-70° C. and an initial pressure of 100-105 bar. After 90 min the required amount of hydrogen had been taken up. The solution was let off and after filtering of the Raney nickel concentrated by evaporation. The dry residue was dissolved in 310 ml of boiling methanol, filtered, and diluted with 360 ml of water.

Provenance & Evidence