2-Chloro-6,7-dimethoxy-4-quinazolinamine → HCID 20531353, compound

HRID 1759589Notes

Reaction equation

HRID 1759589 reaction equation
[CH3:1][S:2][C:3]1[O:7][C:6]([C:8]([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[O:9])=[N:5][N:4]=1.Cl[C:17]1[N:26]=[C:25]([NH2:27])[C:24]2[C:19](=[CH:20][C:21]([O:30][CH3:31])=[C:22]([O:28][CH3:29])[CH:23]=2)[N:18]=1>C(O)CC(C)C>[NH2:27][C:25]1[C:24]2[C:19](=[CH:20][C:21]([O:30][CH3:31])=[C:22]([O:28][CH3:29])[CH:23]=2)[N:18]=[C:17]([N:13]2[CH2:14][CH2:15][CH:10]([C:8]([C:6]3[O:7][C:3]([S:2][CH3:1])=[N:4][N:5]=3)=[O:9])[CH2:11][CH2:12]2)[N:26]=1

Participants

4

Reactant 2

HCID 902352-Chloro-6,7-dimethoxy-4-quinazolinamineHCID 20531357HCID 20531357, compound

Product 1

HCID 20531353HCID 20531353, compound

Reagents, catalysts & solvents 1

HCID 31260Isoamyl AlcoholSolvent

Procedure

2.13 g of 4-(5-methylthio-1,3,4-oxadiazole-2-carbonyl)-piperidine and 2.4 g of 2-chloro-4-amino-6,7-dimethoxy-quinazoline in 50 cm3 of isoamyl alcohol are heated under reflux for 8 hours with stirring. After cooling and concentration, 3.9 g of product are isolated, which are purified by recrystallisation from ethanol.

Workup

  1. temperatureunder reflux for 8 hours
  2. temperatureAfter cooling
  3. concentrationconcentration, 3.9 g of product
  4. customare isolated
  5. customwhich are purified by recrystallisation from ethanol

Sources & evidence

ORD record
ord-b742dd8ddfdf453d95e7328ec0f0e402
Source dataset
uspto-grants-1982_07
Patent number
US04341893

Reaction notes

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