Hydrochloric Acid → HCID 24858722, compound

Participants

Reaction Steps

A mixture of 1,2,3,4,4a,5,6,7-octahydro-2-trimethylsilyloxy-2,5,5-trimethylnaphthalene (0.78 g), ethanol (40 ml), water (4 ml) and 2 N hydrochloric acid (1 ml) was stirred at 20°-25° for 17 h. The mixture was poured onto water and extracted with hexanes. The combined organic extracts were washed with sodium bicarbonate solution and the solvent evaporated to give 0.61 g of crude product. Chromatography gave 0.42 g (75%) of α-ambrinol. Spectral and analytical data for this material was consistent with that given in Example 4.

Provenance & Evidence