Hydrochloric Acid → HCID 22821046, compound

Participants

Reaction Steps

Gaseous HCl is bubbled through a solution of t-boc-gly-phe-NHCH3 8a (9.2 g, 2.7×10-2 mole) and methanol (200 ml). After 1/2 hour the methanol is evaporated at reduced pressure leaving a clear colorless oil which, when triturated with Et2O crystallizes to give 9a as a colorless power: m.p. 220°-223° C. In a similar fashion, gly-phe-leu-NHEt.HCl is prepared from its corresponding t-boc-derivative.

Provenance & Evidence