HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane methanol ammonium hydroxide → N-(2-benzothiazolyl)-O-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-tyrosine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| Reactant | Ethyl N-(2-benzothiazolyl)-O-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-tyrosinate | HCID 86594969 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-(2-benzothiazolyl)-O-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-tyrosine | HCID 86594970 | — |
Reaction Steps
The operation is carried out as for 1-6 but starting with 0.15 ml of 2N soda (0.3 mmole) and 80 mg of 2-1 (0.155 mmole) in 5 ml of ethanol. Rf=0.28 (CH2Cl2/MeOH/NH4OH 90/10/1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06838453B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-aafee938d93a494dba06270f9dc45e5a |
| Source note | uspto-grants-2005_01 |