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HRID1759701

反应详情

EQUATION

反应方程式

HRID 1759701 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)CCCOc1ccc(C[C@H](N)C(=O)OC(C)(C)C)cc1
HCID15512208

tert-Butyl (2S)-2-amino-3-(4-(3-ethoxycarbonylpropyloxy)phenyl)propionate

C19H29NO5

结构：Fc1nnnn1Cc1ccccc1
HCID21942201

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)CCCOc1ccc(C[C@H](Nc2nnnn2Cc2ccccc2)C(=O)OC(C)(C)C)cc1
HCID69733478

未命名化合物

收率 57.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

A solution of aminoester 4-2 (325 mg, 0.92 mmole) and 5-fluoro-1-(phenylmethyl)-1H-tetrazole (170 mg, 0.95 mmole) in 15 ml of pyridine is heated at 100° C. for 2 hours. Evaporation is then carried out under reduced pressure until a dry extract is obtained which is purified by chromatography eluting with a heptane/AcOEt mixture 50/50. 270 mg of the expected product 5-1 is obtained.

WORKUP

后处理

  1. customEvaporation
  2. extractionextract
  3. customis obtained which
  4. customis purified by chromatography
  5. washeluting with a heptane/AcOEt mixture 50/50