HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4,5,6-Tetrahydropyrimidin-2-amine → HCID 69733402, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4,5,6-Tetrahydropyrimidin-2-amine | HCID 3287412 | — |
| Reactant | HCID 86594973 | HCID 86594973 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 69733402 | HCID 69733402 | 96.8% |
Reaction Steps
The ester 6-1 (370 mg) is mixed with 2-amino-1,4,5,6-tetrahydropyrimidine (200 mg) in 5 ml of CH2Cl2 and agitation is carried out at ambient temperature for 6 hours. The reaction medium is then evaporated under reduced pressure and the dry extract obtained is purified by chromatography eluting with a CH2Cl2/MeOH/water/AcOH mixture 90/10/1/1. 200 mg of the expected product 6-2 is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06838453B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-f0c97753852b4eedb50bd09f540f9439 |
| Source note | uspto-grants-2005_01 |