反应详情

A mixture constituted by (1,1-dimethyl ethyl) L-tyrosinate 4-1 (120 mg, 0.5 mmole) and fluorobenzothiazole (75 mg; 0.5 mmole) in 3 ml of pyridine is heated under reflux for 2 hours. The reaction medium is then evaporated under reduced pressure until a dry extracted is obtained which is purified by chromatography eluting with a heptane/ethyl acetate mixture (100/0→0/100). 115 mg of expected product is obtained.

1. temperatureis heated
2. temperatureunder reflux for 2 hours
3. customThe reaction medium is then evaporated under reduced pressure until a dry
4. extractionextracted
5. customis obtained which
6. customis purified by chromatography
7. washeluting with a heptane/ethyl acetate mixture (100/0→0/100)