HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4,5,6-Tetrahydropyrimidin-2-amine → HCID 86594980, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4,5,6-Tetrahydropyrimidin-2-amine | HCID 3287412 | — |
| Reactant | HCID 18176952 | HCID 18176952 | — |
| Reactant | HCID 86594978 | HCID 86594978 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 86594980 | HCID 86594980 | — |
Reaction Steps
80 mg of 2-amino-1,4,5,6-tetrahydropyrimidine is added to a solution of the ester 8-2 (123 mg) in 3 ml of THF, agitation is carried out for 20 hours at ambient temperature, 48 mg of tetrahydroaminopyrimidine is also added and agitation is carried out for 5 hours. After evaporating under reduced pressure, the mixture is chromatographed eluting with a CH2Cl2/AcOEt 80/20 then CH2Cl2/MeOH 90/10 mixture. 68 mg of the expected 8-3 is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06838453B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-09eea61a02544d91825633276b7fb859 |
| Source note | uspto-grants-2005_01 |