HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(5-bromo-2-benzoxazolyl)-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]propyl]benzoyl]amino]-L-alanine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (1,1-dimethyl ethyl) N-(5-bromo-2-benzoxazolyl)-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]propyl]benzoyl]amino]-L-alaninate | HCID 69733401 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(5-bromo-2-benzoxazolyl)-3-[[4-[3-oxo-3-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]propyl]benzoyl]amino]-L-alanine | HCID 69709945 | 117.9% |
Reaction Steps
Hydrolysis of the ester is carried out as in the previous examples, but starting from 56 mg of 10-7 and 2.5 ml of TFA in 2.5 ml of dichloromethane. 60 mg of 10-8 is obtained (in the form of the trifluoroacetic acid salt).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06838453B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-7e437443b5de48b5bfecf0b3ad336e46 |
| Source note | uspto-grants-2005_01 |