反应详情

At 0° C. 7.0 g (20.7 mmol) of 2-(2-ethoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one (Example 15A) are added carefully to 24.1 g (207 mmol) of chlorosulphuric acid. The mixture is allowed to warm to room temperature and stirred overnight. The solution is carefully added to 200 ml of ice-water and extracted twice with dichloromethane. The combined organic phases are dried over sodium sulphate and the solvent is distilled off under reduced pressure. The sulphonyl chloride is dried under reduced pressure and reacted further to the sulphonamides without further purification.

1. customAt 0° C
2. extractionextracted twice with dichloromethane
3. dry with materialThe combined organic phases are dried over sodium sulphate
4. distillationthe solvent is distilled off under reduced pressure
5. dry with materialThe sulphonyl chloride is dried under reduced pressure
6. customreacted further to the sulphonamides without further purification