Sulfuryl chloride → HCID 136481385, compound

HRID 1759736Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:25])[N:18]=[C:19]([CH2:20][CH:21]([CH2:23][CH3:24])[CH3:22])[N:12]2[N:11]=1)[CH3:2].[S:26](Cl)([Cl:29])(=[O:28])=[O:27]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:26]([Cl:29])(=[O:28])=[O:27])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:25])[N:18]=[C:19]([CH2:20][CH:21]([CH2:23][CH3:24])[CH3:22])[N:12]2[N:11]=1)[CH3:2]

Participants

Reactant 2

HCID 24648Sulfuryl chloride

HCID 136481365HCID 136481365, compound

Product 1

HCID 136481385HCID 136481385, compound

Procedure

The preparation is carried out analogously to the procedure of Example 27A using 7.23 g (0.12 mmol) of 2-(2-ethoxyphenyl)-5-methyl-7-(2-ethylpropyl)-1H-imidazo-[5,1-f][1,2,4]-triazin-4-one (Example 18A). This gives 8.56 g (91.9%) of sulphonyl chloride as a white solid which is directly reacted further.

Sources & evidence

ORD record: ord-92b09208be2844198dcacdb7fc2e970f
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06838459B1

Reaction notes

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