Sulfuryl chloride → HCID 136481430, compound

HRID 1759737Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:29])[N:18]=[C:19]([CH2:20][CH:21]([CH2:27][CH3:28])[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:12]2[N:11]=1)[CH3:2].[S:30](Cl)([Cl:33])(=[O:32])=[O:31]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:30]([Cl:33])(=[O:32])=[O:31])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:29])[N:18]=[C:19]([CH2:20][CH:21]([CH2:27][CH3:28])[CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[N:12]2[N:11]=1)[CH3:2]

Participants

Reactant 2

HCID 24648Sulfuryl chloride

HCID 135552968HCID 135552968, compound

Product 1

HCID 136481430HCID 136481430, compound

Procedure

The preparation is carried out analogously to the procedure of Example 27A using 5.6 g (14.1 mmol) of 2-(2-ethoxyphenyl)-5-methyl-7-(2-ethylheptyl)-3H-imidazo-[5,1-f][1,2,4]-triazin-4-one (Example 19A). This gives 3.7 g (52.9%) of sulphonyl chloride as a slightly yellow foam which is directly reacted further.

Sources & evidence

ORD record: ord-8626bce7474947a199bcd48187d74f88
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06838459B1

Reaction notes

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