Chlorosulfonic acid → HCID 136115483, compound

HRID 1759742Notes

Reaction equation

HRID 1759742 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:27])[N:18]=[C:19]([CH2:20][CH:21]([CH2:24][CH2:25][CH3:26])[CH2:22][CH3:23])[N:12]2[N:11]=1)[CH3:2].[S:28]([Cl:32])(=O)(=[O:30])[OH:29].S(Cl)(Cl)(=O)=O>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:28]([Cl:32])(=[O:30])=[O:29])=[CH:6][C:5]=1[C:10]1[NH:15][C:14](=[O:16])[C:13]2=[C:17]([CH3:27])[N:18]=[C:19]([CH2:20][CH:21]([CH2:24][CH2:25][CH3:26])[CH2:22][CH3:23])[N:12]2[N:11]=1)[CH3:2]

Participants

4

Reactant 3

HCID 24638Chlorosulfonic acidHCID 24648Sulfuryl chlorideHCID 136015763HCID 136015763, compound

Product 1

HCID 136115483HCID 136115483, compound

Procedure

The preparation is carried out analogously to the procedure of Example 27A using 300 mg (0.81 mmol) of 2-(2-ethoxyphenyl)-5-methyl-7-(2-n-propylbutyl)-3H-imidazo[5,1-f][1,2,4]-triazin-4-one (Example 25A) and 950 mg. (8.1 mmol) of chlorosulphuric acid. This gives 300 g (78.9%) of sulphonyl chloride which is directly reacted further.

Sources & evidence

ORD record
ord-1e4d0165f8f04ba5bf097a4e2570d631
Source dataset
uspto-grants-2005_01
Patent number
US06838459B1

Reaction notes

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