Ethyl Acetate → HCID 86588612, compound

Participants

Reaction Steps

A solution of 4-[3-(4-benzyloxy-butyl)-3-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-ureido]-benzoic acid (41) (0.51 g, 0.96 mmole) in 50 mL ethyl acetate, containing 80 mg of 10% palladium on charcoal, was maintained under 1 atmosphere of hydrogen overnight. The mixture was filtered over Celite and volatile material was removed in vacuo. Trituration in hexanes afforded 380 mg (90%) of 4-[3-(4-hydroxy-butyl)-3-(5,5,8,8-tetramethyl -5,6,7,8-tetrahydro-naphthalen-2-yl)-ureido]-benzoic acid (71) as a white solid. M.P. 124-125° C.

Provenance & Evidence