反应详情

温度

80 °C

To 2 ml of N,N-dimethylformamide were added 183 mg of 4-chloro-6-(2-butynyloxy)pyrimidine, 166 mg of potassium carbonate, and 138 mg of 2,3-methylenedioxyphenol, followed by stirring at 80° C. for 7 hours and then at 120° C. for 3 hours. The reaction mixture was then left for cooling to room temperature and subjected to phase separation three times between ethyl acetate and an aqueous sodium chloride solution. The organic layers were dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography to give 193 mg of 4-(2-butynyloxy)-6-(2,3-methylenedioxyphenoxy)pyrimidine (the present compound (64)).

1. waitat 120° C. for 3 hours
2. waitThe reaction mixture was then left
3. temperaturefor cooling to room temperature
4. customsubjected to phase separation three times between ethyl acetate
5. dry with materialThe organic layers were dried over anhydrous magnesium sulfate
6. concentrationconcentrated