Water → HCID 22599870, compound

Participants

Reaction Steps

In 9 ml of N,N-dimethylformamide were dissolved 202 mg of 4-chloro-6-(2,3-difluorophenyl)pyrimidine and 112 mg of 2-pentyn-1-ol, to which 54 mg of sodium hydride (60% in oil) was added, followed by stirring at room temperature for 5 hours. The reaction mixture was then poured into water and extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated. The resulting residue was subjected to silica gel column chromatography to give 211 mg of 4-(2,3-difluorophenyl)-6-(2-pentynyloxy)pyrimidine (the present compound (117)).

Provenance & Evidence