4,6-Dichloropyrimidine → HCID 22599839, compound

HRID 1759962Notes

Reaction equation

HRID 1759962 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[F:9][C:10]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>C(O)C>[Cl:8][C:6]1[CH:7]=[C:2]([NH:12][C:11]2[CH:13]=[CH:14][CH:15]=[C:16]([F:17])[C:10]=2[F:9])[N:3]=[CH:4][N:5]=1

Participants

4

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 782782,3-Difluoroaniline

Product 1

HCID 22599839HCID 22599839, compoundYield 98.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 14 ml of ethanol were added 2.2 g of 4,6-dichloropyrimidine and 2.3 g of 2,3-difluoroaniline, followed by heating under reflux for 6 hours. The reaction mixture was then left for cooling to room temperature and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate to give 3.5 g of 4-chloro-6-(2,3-difluoroanilino)pyrimidine.

Workup

  1. temperatureby heating
  2. temperatureunder reflux for 6 hours
  3. waitThe reaction mixture was then left
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-f7625f0085a648e389a04b0f214ff6b7
Source dataset
uspto-grants-2005_01
Patent number
US06838463B2

Reaction notes

Loading…