Ammonium Chloride → HCID 22599669, compound

Participants

Reaction Conditions

Reaction Steps

To 2 ml of ethanol was suspended 0.3 g of 6-methylthio-4-benzoylpyrimidine, to which 0.07 g of sodium borohydride was added, followed by stirring at 0° C. for 4 hours. The reaction mixture was then poured into a saturated aqueous ammonium chloride solution and extracted three times with ethyl acetate. The organic layers were combined and washed with a saturated aqueous sodium chloride solution, and the combined organic layer was dried over anhydrous magnesium sulfate and then concentrated to give 6-methylthio-4-(α-hydroxybenzyl)pyrimidine.

Provenance & Evidence