反应详情

温度

120 °C

A mixture 3-chloro-5-methylphenylacetonitrile (13.3 g; from step (ii) above) and KOH (17 g; 0.3 mol) in 150 mL of water:i-PrOH (2:1) was heated while stirring in an autoclave at 120° C. overnight and then at room temperature for 2 days. The i-PrOH was evaporated and the remainder was acidified (6M HCl) to pH 2 and extracted 3 times with ether. The combined organic layers were washed twice with water, dried (Na2SO4), and evaporated to yield the sub-title compound (10.4 g; 70%).

1. waitat room temperature for 2 days
2. customThe i-PrOH was evaporated
3. extractionextracted 3 times with ether
4. washThe combined organic layers were washed twice with water
5. dry with materialdried (Na2SO4)
6. customevaporated