反应详情

To an ice cooled solution of 2-chloro-5-(Boc-amino)benzyl alcohol (7.4 g; 29 mmol; from step (i) above) in CH2Cl2 (100 mii) was added TEA (2.9 g; 29 mmol), followed by MsCl (3.3 g, 29 mmol; added dropwise). After stirring for 2 hours the resultant mixture was poured onto water. The organic layer was separated, washed with water, dried (Na2SO2) and concentrated to yield 10 g (100%) of the sub-title compound.

1. additionadded dropwise)
2. additionwas poured onto water
3. customThe organic layer was separated
4. washwashed with water
5. dry with materialdried (Na2SO2)
6. concentrationconcentrated