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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1760057Generated: October 31, 2026

Orotic Acid → Creatine orotate

https://huagongshe.com/reaction/1760057

Reaction equation

Participants

RoleNameHCIDCharge
ReactantOrotic AcidHCID 967—
ReactantCreatine MonohydrateHCID 80116—
SolventEthanolHCID 702—
ProductCreatine orotateHCID 12135009—

Reaction Steps

Under room temperature 149 grams of creatine monohydrate is slowly added to 1.5 liters of ethanol under agitation and stirring for 30 minutes. Then 156 grams of orotic acid is slowly added to the mixture during continuous stirring for 4 hours under room temperature. Finally filtration is utilized to remove the solvent and clean the residue with ethanol. After drying 272 grams of creatine orotate is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06838562B2
Source datasetuspto-grants-2005_01
ORD IDord-7cb800b82f354274baef838f542136f9
Source noteuspto-grants-2005_01