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HRID1760062

反应详情

EQUATION

反应方程式

HRID 1760062 的结构方程式

REACTANTS

反应物

1
结构：CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C
HCID148124

Docetaxel

C43H53NO14

PRODUCTS

生成物

1
结构：CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C.O.O.O
HCID24721032

未命名化合物

收率 338.2%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

Docetaxel (460 gm obtained from step 2b) is dissolved in filtered acetonitrile (13.8 L) at 68° C. under stirring. To this solution purified water (41.4 L) is added slowly and then the mixture is stirred further at 15-20° C. for 3h. The precipitated material is filtered and then dried at 36° C. under 650 mm mercury vacuum for 36h to obtain docetaxel trihydrate (415 gm, C.P. 99.59%, assay 99.2% on dry basis, water content 6.8%).

WORKUP

后处理

  1. customTo this solution purified water (41.4 L)
  2. additionis added slowly
  3. stirringthe mixture is stirred further at 15-20° C. for 3h
  4. filtrationThe precipitated material is filtered
  5. dry with materialdried at 36° C. under 650 mm mercury vacuum for 36h