反应详情

Potassium carbonate (583 mg, 4.22 mmol) was added to an ethanol solution (10 ml) of ethyl 3-[(trimethylsilyl)ethynyl]benzoate (1.04 g, 4.22 mmol), and stirred at room temperature for 2 h. The mixture was concentrated, and the residue was dissolved in ethyl acetate. The organic layer was washed with water and then brine, dried over sodium sulfate and concentrated. The residue was purified by silica gel flash column chromatography (eluent: hexane/ethyl acetate=30/1) to give ethyl 3-ethynylbenzoate (96%).

1. concentrationThe mixture was concentrated
2. dissolutionthe residue was dissolved in ethyl acetate
3. washThe organic layer was washed with water
4. dry with materialbrine, dried over sodium sulfate
5. concentrationconcentrated
6. customThe residue was purified by silica gel flash column chromatography (eluent: hexane/ethyl acetate=30/1)