Tert-butoxycarbonylalanine → HCID 69269260, compound

HRID 1760093Notes

Reaction equation

HRID 1760093 reaction equation
[CH3:1][C@H:2]([NH:6]C(OC(C)(C)C)=O)[C:3](O)=[O:4].[ClH:14].N[CH:16]1[CH2:22][C:21]([CH3:24])([CH3:23])[CH:20]=[N:19][C:18]2[CH:25]=[CH:26][CH:27]([CH3:30])[C:28](=[O:29])[C:17]1=2.Cl.[NH2:32][C@H](C(NC1CC(C)(C)C=NC2C=CC(C)C(=O)C1=2)=O)C>>[ClH:14].[NH2:6][C@H:2]([C:3]([CH:16]1[CH2:22][C:21]([CH3:24])([CH3:23])[C:20]([NH2:32])=[N:19][C:18]2[CH:25]=[CH:26][CH:27]([CH3:30])[C:28](=[O:29])[C:17]1=2)=[O:4])[CH3:1]

Participants

4

Reactant 3

HCID 85082Tert-butoxycarbonylalanineHCID 22312448HCID 22312448, compoundHCID 69735457HCID 69735457, compound

Product 1

HCID 69269260HCID 69269260, compound

Procedure

Following the General Procedure H and using N-t-Boc-L-alanine and 5-amino-3,3,7-trimethyl-5,7-dihydro-6H-benz[b]azepin-6-one hydrochloride (Example 1-C), 5-(N-t-Boc-L-alaninyl)amino-3,3,7-trimethyl-5,7-dihydro-6H-benz[b]azepine-6-one was prepared. Following the General Procedure (Example 1-C, Step B) and using 5-(N-t-Boc-L-alaninyl)amino-3,3,7-trimethyl-5,7-dihydro-6H-benz[b]azepin-6-one, 5-(L-alaninyl)amino-3,3,7-trimethyl-5,7-dihydro-6H-benz[b]azepin-6-one hydrochloride was prepared.

Workup

  1. customwas prepared
  2. customwas prepared

Sources & evidence

ORD record
ord-e47007f80f274893a4517d9e271ebcae
Source dataset
uspto-grants-2005_01
Patent number
US06838455B2

Reaction notes

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