Tert-butoxycarbonylalanine → HCID 11626239, compound

HRID 1760100Notes

Reaction equation

[C:1]([NH:8][C@H:9]([C:11]([OH:13])=O)[CH3:10])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[NH2:14][CH:15]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[C:19]2[CH:26]=[CH:27][CH:28]=[C:29]3[CH2:30][CH2:31][CH2:32][N:17]([C:18]=23)[C:16]1=[O:33]>>[C:1]([NH:8][C@H:9]([C:11]([NH:14][CH:15]1[C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[C:19]2[CH:26]=[CH:27][CH:28]=[C:29]3[CH2:30][CH2:31][CH2:32][N:17]([C:18]=23)[C:16]1=[O:33])=[O:13])[CH3:10])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])=[O:2]

Participants

Reactant 2

HCID 85082Tert-butoxycarbonylalanine

HCID 9881732HCID 9881732, compound

Product 1

HCID 11626239HCID 11626239, compound

Procedure

Following General Procedure D and using N-Boc-Alanine (Aldrich) and 9-amino-5,6-dihydro-4H-quino[8,1-ab][3]benzazepin-8(9H)-one (from Example 3-AB), the title compound was prepared.

Sources & evidence

ORD record: ord-04149f48b0844a738f97ec7ca5299b0f
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06838455B2

Reaction notes

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