HCID 69033852, compound → 209985-36-4

HRID 1760101Notes

Reaction equation

HRID 1760101 reaction equation
C(OC([C:11]1([NH2:32])[N:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:15]2[CH:25]=[C:26](Br)[CH:27]=[CH:28][C:14]=2[N:13]([CH3:30])[C:12]1=[O:31])=O)C1C=CC=CC=1>[Pd].CO>[NH2:32][CH:11]1[N:17]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:15]2[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=2[N:13]([CH3:30])[C:12]1=[O:31]

Participants

4

Reactant 1

HCID 69033852HCID 69033852, compound

Product 1

HCID 14423345209985-36-4

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A flask was charged with 3-(benzyloxycarbonyl)-amino-7-bromo-2,3-dihydro-1-methyl-5-(2-fluorophenyl)-1H-1,4-benzodiazepin-2-one (1 eq.; Example 4-D, Step A) and 10% palladium on carbon. Methanol was added, and the flask was placed under a balloon of H2. The reaction was stirred for 21 hours. The mixture was filtered through celite washing with methanol. The filtrate was concentrated to a white solid.

Workup

  1. filtrationThe mixture was filtered
  2. washthrough celite washing with methanol
  3. concentrationThe filtrate was concentrated to a white solid

Sources & evidence

ORD record
ord-4d50f4792f3842e9ac55b91feee04e4d
Source dataset
uspto-grants-2005_01
Patent number
US06838455B2

Reaction notes

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