Tert-butoxycarbonylalanine → HCID 69735662, compound

HRID 1760109Notes

Reaction equation

HRID 1760109 reaction equation
[NH2:1][CH:2]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]([CH3:19])[C:3]1=[O:20].C([NH:28][C@H:29]([C:31](O)=[O:32])[CH3:30])(OC(C)(C)C)=O>>[NH2:28][C@H:29]([C:31]([C:2]1([NH2:1])[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[C:6]2[CH:15]=[CH:16][CH:17]=[CH:18][C:5]=2[N:4]([CH3:19])[C:3]1=[O:20])=[O:32])[CH3:30]

Participants

3

Reactant 2

HCID 85082Tert-butoxycarbonylalanineHCID 21955715HCID 21955715, compound

Product 1

HCID 69735662HCID 69735662, compound

Procedure

Following General Procedure D above using 3-amino-1,3-dihydro-1-methyl-5-(1-piperidinyl)-2H-1,4-benzodiazepin-2-one (Example 4-A) and N-Boc Alanine (Novabiochem), the title compound was prepared as a white foam.

Sources & evidence

ORD record
ord-20ad3bdceb0b451780fd89a8330630c8
Source dataset
uspto-grants-2005_01
Patent number
US06838455B2

Reaction notes

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