Alanine methyl ester hydrochloride → HCID 131723865, compound

HRID 1760126Notes

Reaction equation

HRID 1760126 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]2[O:11][CH2:10]2)[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.C[O:14][C:15](=[O:19])[C@H:16]([CH3:18])[NH2:17]>>[OH:11][CH:9]([C:4]1[CH:5]=[C:6]([F:8])[CH:7]=[C:2]([F:1])[CH:3]=1)[CH2:10][NH:17][C@H:16]([C:15]([OH:19])=[O:14])[CH3:18]

Participants

3

Reactant 2

HCID 2733257Alanine methyl ester hydrochlorideHCID 22599530HCID 22599530, compound

Product 1

HCID 131723865HCID 131723865, compound

Procedure

Following General Procedure EB and reacting 2-(3,5-difluorophenyl)-1,2-epoxyethane (Example EC1) and L-alanine methyl ester hydrochloride (Bachem), the title compound was isolated after flash chromatography with 3:1 to 1:1 (gradient) hexanes/ethyl acetate.

Sources & evidence

ORD record
ord-064d5ca18676407999e56c92272628f2
Source dataset
uspto-grants-2005_01
Patent number
US06838455B2

Reaction notes

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