3,5-Bis(trifluoromethyl)benzaldehyde → 2-[3,5-Bis(trifluoromethyl)phenyl]oxirane

HRID 1760129Notes

Reaction equation

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:10]=1)[CH:6]=[O:7].[CH3:17]CCCC.C(OCC)C>>[F:1][C:2]([F:15])([F:16])[C:3]1[CH:4]=[C:5]([CH:6]2[O:7][CH2:17]2)[CH:8]=[C:9]([C:11]([F:14])([F:12])[F:13])[CH:10]=1

Participants

Reactant 2

HCID 1362473,5-Bis(trifluoromethyl)benzaldehyde

HCID 21877078Diethylether pentane

Product 1

HCID 139032682-[3,5-Bis(trifluoromethyl)phenyl]oxirane

Procedure

Following General Procedure EC and using 3,5-bis-(trifluoromethyl)-benzaldehyde (Lancaster), the title compound was isolated after flash chromatography with 10:1 pentane/diethylether.

Sources & evidence

ORD record: ord-0afe5c6a6fed45ddbb676faf5fce8cea
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06838455B2

Reaction notes

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