HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Pyroglutamic Acid → 5-oxo-L-prolyl-L-glutamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Pyroglutamic Acid | HCID 7405 | — |
| Reactant | Pivaloyl chloride | HCID 62493 | — |
| Reactant | HCID 5287779 | HCID 5287779 | — |
| Product | 5-oxo-L-prolyl-L-glutamine | HCID 11010621 | — |
Reaction Steps
A mixed anhydride from L-pyroglutamic acid 9 and pivaloyl chloride was coupled with L-glutamine t-butyl ester 10 followed by acidic workup to yield L-pyroglutamyl-L-glutamine 7 (Equation 2). This dipeptide was purified by reversed phase HPLC using a gradient system of acetonitrile/H2O.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06841530B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-59ef154b662045288986d2e4bfa7b4f4 |
| Source note | uspto-grants-2005_01 |