HCID 22597445, compound → HCID 22597433, compound

Participants

Reaction Steps

The free amine (371 mg) obtained in Example 35 was dissolved in THF (200 ml) and EtOH (200 ml), and 10% Pd—C (hydrous, 0.5 g) was added thereto, and the mixture was stirred for 2 hours in a hydrogen atmosphere at room temperature. The reaction mixture was filtered with Celite, and the filtrate was evaporated, to give 300 mg of the title compound in free form. This free amine (100 mg) was dissolved in methanol (2 ml), then 4N HCl/EtOAc (0.2 ml) was added thereto, and the precipitated crystals were collected by f iltration, to give 84 mng of the title compound.

Provenance & Evidence