Azane;hydrate → HCID 12136903, compound

HRID 1760221Notes

Reaction equation

HRID 1760221 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2C=[N:16][C:15]3[C:10]2=[N:11][CH:12]=[N:13][C:14]=3[Cl:18])=[CH:5][N:4]=1.O.N>C(COC)OC>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([NH:9][C:10]2[C:15]([NH2:16])=[C:14]([Cl:18])[N:13]=[CH:12][N:11]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 12896473Azane;hydrateHCID 22597431HCID 22597431, compound

Product 1

HCID 12136903HCID 12136903, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
70 °C

Procedure

A mixture of 25 g of 5-(6-chloro-9H-9-purinyl)-2-pyridyl methyl ether, 250 mL conc. ammonia water and 500 mL dimethoxyethane was stirred at 70° C. for 4 hours, and the resulting suspension was filtered, to give 21.2 g of the title compound as white crystals (91% y.). (4) 8-Bromo-9-(6-methoxy-3-pyridyl)-9H-6-purineamine

Workup

  1. filtrationthe resulting suspension was filtered

Sources & evidence

ORD record
ord-bd11a41ac93f403f88eb5a27ea3149bd
Source dataset
uspto-grants-2005_01
Patent number
US06841549B1

Reaction notes

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