Dimethylformamide → HCID 22597776, compound

Participants

Reaction Steps

5-Chlorothiophene-2-carboxylic acid (214 mg; 1.3 mmol), ethyldimethylaminopropyl carbodiimide (250 mg; 1.3 mmol) and 1-hydroxybenzotriazole (176 mg; 1.3 mmol) in dry DMF (25 ml) was stirred at room temperature for 30 min. A solution of the N-boc amine D6 (300 mg; 1.21 mmol) in dichloromethane (5 ml) was added and the mixture kept at room temperature overnight. Work-up gave a pink gum which was chromatographed on Kieselgel 60 in 30% ethyl acetate-hexane. Combination of appropriate fractions gave the title compound as an off white solid (0.5 g).

Provenance & Evidence