Methylamine → HCID 22597714, compound

Participants

Reaction Steps

A solution of the amine D5 (162 mg; 1.0 mmol) and 3-bromo-4-tert-butylbenzoic acid (257 mg; 1.0 mmol) in anhydrous N,N-dimethylformamide (7 ml), was treated with 1-hydroxybenzotriazole (135 mg; 1.0 mmol) and 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide (192 mg; 1.0 mmol) at 25° C. The mixture was shaken for 48 h before extracting the product into dichloromethane and washing with 10% aqueous NaHCO3, water and finally brine. The organic layer was dried over MgSO4 and evaporated in vacuo to afford 373 mg of the title compound in 93% yield.

Provenance & Evidence