4-Methoxy-3-(trifluoromethyl)benzoyl chloride → HCID 22597710, compound

HRID 1760253Notes

Reaction equation

HRID 1760253 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH2:7][N:8]([CH:12]=[O:13])[CH2:9]2)=[CH:4][CH:3]=1.[CH3:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](Cl)=[O:21])=[CH:18][C:17]=1[C:25]([F:28])([F:27])[F:26]>>[CH:12]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][C:2]([NH:1][C:20](=[O:21])[C:19]3[CH:23]=[CH:24][C:16]([O:15][CH3:14])=[C:17]([C:25]([F:28])([F:26])[F:27])[CH:18]=3)=[CH:3][CH:4]=2)[CH2:9]1)=[O:13]

Participants

3

Reactant 2

HCID 27752984-Methoxy-3-(trifluoromethyl)benzoyl chlorideHCID 22597739HCID 22597739, compound

Product 1

HCID 22597710HCID 22597710, compound

Procedure

7-Amino-2-formyl-1,2,3,4-tetrahydroisoquinoline (0.176 g) was converted into the title compound by reaction with 4-methoxy-3-trifluoromethylbenzoyl chloride, following the procedure of Example 3. The product was isolated as a white solid (0.035 g).

Sources & evidence

ORD record
ord-a3f7cb19b41442668983b0198e286d0c
Source dataset
uspto-grants-2005_01
Patent number
US06841560B2

Reaction notes

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