Nitric Acid → HCID 131724705, compound

Participants

Reaction Steps

In 4 ml of acetic anhydride there was suspended (2-(2-thienyl)-2-carbamoyloxyethyl)oxocarboxamide (0.50 g) and the resulting mixture was cooled to 0°. A mixture of nitric acid (60% in water 0.37 g) in 4 ml of acetic acid was added dropwise and the mixture was stirred at room temperature for 1.5 hours, poured into 100 ml of ice water, extracted with ethyl acetate and washed with saturated brine. The extracts were dried over sodium sulfate, filtered, concentrated and purified by recrystallization from ether to yield the title compound as a yellow solid (0.07 g, yield 12%). M.p. 145-1847 (from ether).

Provenance & Evidence