Aniline → 1-Phenoxy-2,2,6,6-tetramethylpiperidine

Participants

Reaction Steps

The procedure of Example 5 is repeated using 1.95 g (12.5 mmol) of 2,2,6,6-tetramethylpiperidine-1-oxyl, 3.09 g (30.0 mmol) of tert-butylnitrite and 228 mg (˜0.125 mmol) of phosphomolydbic acid hydrate (H3PMo12O40) in 100 mL of pyridine and 2.32 g (25 mmol) of aniline in 5 mL of pyridine. The crude is purified by vacuum flash chromatography (heptane) to give 2.0 g of a colorless oil in 68.7% yield.

Provenance & Evidence