2-Chlorooxane → N-(2-tetrahydropyranyloxy)-tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-amine

HRID 1760392Notes

Reaction equation

[CH2:1]([O:4][N:5]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:6]([CH3:15])([CH3:14])[C:7]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH:2]=[CH2:3].C(N([C:26](C)(C)[C:27](NC(C)(C)C)=[O:28])O)(C)(C)C.ClC1CCCCO1>>[O:28]1[CH2:27][CH2:26][CH2:3][CH2:2][CH:1]1[O:4][N:5]([C:16]([CH3:19])([CH3:18])[CH3:17])[C:6]([CH3:15])([CH3:14])[C:7]([NH:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8]

Participants

Reactant 3

HCID 5244002-Chlorooxane

HCID 11207972N-allyloxy-tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-amine

HCID 22182216Tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-hydroxylamine

Product 1

HCID 22598546N-(2-tetrahydropyranyloxy)-tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-amineYield 33%

Procedure

The compound is prepared in analogy to compound (204) from tert-butyl-(dimethyl-tert-butylaminocarbonyl-methyl)-hydroxylamine and 2-chlor-tetrahydropyrane in 33% yield as colorless oil.

Sources & evidence

ORD record: ord-96afc3a3fef74a91b8fef47b5123f230
Source dataset: uspto-grants-2005_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06841703B2

Reaction notes

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