HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Nitrobenzaldehyde → HCID 22597584, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Nitrobenzaldehyde | HCID 7449 | — |
| Reactant | Ethyl cyanoacetate | HCID 7764 | — |
| Reactant | Ethyl Thioglycolate | HCID 12185 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 2-Methyl-2-thiopseudourea sulfate | HCID 75270 | — |
| Solvent | Ethylacetate heptane | HCID 21899848 | — |
| Product | HCID 22597584 | HCID 22597584 | — |
Reaction Steps
Cyclization of S-methylisothiourea sulfate (700 mg), 3-nitrobenzaldehyde (750 mg) and ethyl cyanoacetate (560 μl), treatment of the product with POCl3 and subsequent reaction with ethyl 2-mercaptoacetate were performed according to the methods described in example 1. The pure title compound was obtained after chromatography on silicagel in heptane/EtOAc=3/2 (v/v) as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06841553B2 |
| Source dataset | uspto-grants-2005_01 |
| ORD ID | ord-502d37601e68407790ce127d88fddef9 |
| Source note | uspto-grants-2005_01 |