2-Methyldodecanoic acid → 2,2-Dimethyldodecanoyl chloride

HRID 1760505Notes

Reaction equation

HRID 1760505 reaction equation
[CH3:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([Cl:5])=[O:4].[CH3:16]C(CCCCCCCCCC)C(O)=O>>[CH3:1][C:2]([CH3:16])([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([Cl:5])=[O:4]

Participants

3

Reactant 2

HCID 1028932-Methyldodecanoic acidHCID 22595332HCID 22595332, compound

Product 1

HCID 156564322,2-Dimethyldodecanoyl chloride

Procedure

In a similar manner to that described in Example 25 except for the use of 2-methyldodecanoyl chloride [synthesized by chlorinating 2-methyldodecanoic acid which was synthesized by the process described in Organic Synthesis, 4, 616, by the method as described in B. D. Roth, et al., Journal of Medicinal Chemistry, 35, 1609-1617 (1992)] instead of 2,2-dimethyldodecanoyl chloride, 82.5 mg of the desired compound was obtained as a white powder.

Workup

  1. customsynthesized
  2. customwas synthesized by the process
  3. customdescribed in Organic Synthesis, 4, 616, by the method

Sources & evidence

ORD record
ord-a45a2da1816f4a00896b8abfd8c8fc2d
Source dataset
uspto-grants-2005_01
Patent number
US06844173B2

Reaction notes

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