4-Amino-2,2,6,6-tetramethylpiperidine → HCID 22595980, compound

HRID 1760537Notes

Reaction equation

HRID 1760537 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[N:3]=1.[NH2:18][CH:19]1[CH2:24][C:23]([CH3:26])([CH3:25])[NH:22][C:21]([CH3:28])([CH3:27])[CH2:20]1>O>[ClH:1].[ClH:1].[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:4]2[N:3]=[C:2]([NH:18][CH:19]3[CH2:20][C:21]([CH3:28])([CH3:27])[NH:22][C:23]([CH3:26])([CH3:25])[CH2:24]3)[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:5]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 11471129HCID 11471129, compound

Product 1

HCID 22595980HCID 22595980, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
150 °C

Procedure

A mixture of 534 mg of 4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine and 1.8 g of 4-amino-2,2,6,6-tetramethylpiperidine was heated at 150° C. for 2 hours with stirring. After cooling, 20 ml of water were added and the mixture was stirred at room temperature. The white precipitate was filtered off with suction, dried in vacuo and taken up in 20 ml of ethyl acetate. By addition of hydrogen chloride, the title compound was precipitated, filtered off with suction and dried in vacuo. Yield: 0.8 g.

Workup

  1. temperatureAfter cooling
  2. stirringthe mixture was stirred at room temperature
  3. filtrationThe white precipitate was filtered off with suction
  4. customdried in vacuo
  5. additionBy addition of hydrogen chloride
  6. customthe title compound was precipitated
  7. filtrationfiltered off with suction
  8. customdried in vacuo

Sources & evidence

ORD record
ord-91c93b4984184741933536acf0db4e14
Source dataset
uspto-grants-2005_01
Patent number
US06844347B1

Reaction notes

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