反应详情

温度

150 °C

A mixture of 534 mg of 4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine and 1.8 g of 4-amino-2,2,6,6-tetramethylpiperidine was heated at 150° C. for 2 hours with stirring. After cooling, 20 ml of water were added and the mixture was stirred at room temperature. The white precipitate was filtered off with suction, dried in vacuo and taken up in 20 ml of ethyl acetate. By addition of hydrogen chloride, the title compound was precipitated, filtered off with suction and dried in vacuo. Yield: 0.8 g.

1. temperatureAfter cooling
2. stirringthe mixture was stirred at room temperature
3. filtrationThe white precipitate was filtered off with suction
4. customdried in vacuo
5. additionBy addition of hydrogen chloride
6. customthe title compound was precipitated
7. filtrationfiltered off with suction
8. customdried in vacuo