Morpholine → HCID 22595985, compound

HRID 1760538Notes

Reaction equation

HRID 1760538 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)[N:3]=1.[NH:18]1[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1>O>[Cl:17][C:14]1[CH:15]=[CH:16][C:11]([C:4]2[N:3]=[C:2]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[N:5]=2)=[CH:12][CH:13]=1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 11471129HCID 11471129, compound

Product 1

HCID 22595985HCID 22595985, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 267 mg of 4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine and 522 mg of morpholine was heated at 130° C. for 2 hours. After cooling, 20 ml of water were added, the mixture was stirred, and the solid was filtered off with suction and dried at 50° C. in vacuo. Yield: 0.28 g.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off with suction
  3. customdried at 50° C. in vacuo

Sources & evidence

ORD record
ord-156b5646cd3b40188857c28bbd8d31cc
Source dataset
uspto-grants-2005_01
Patent number
US06844347B1

Reaction notes

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